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Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum
S J James; et al
3 de junho de 2013
The elucidation of epigenetic alterations in the autism brain has potential to provide new insights into the molecular mechanisms underlying abnormal gene expression in this disorder. Given strong evidence that engrailed-2 (EN-2) is a developmentally expressed gene relevant...


A randomised controlled trial of bumetanide in the treatment of autism in children
E Lemonnier; et al
3 de junho de 2013
Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility...


Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism
R A Clarke; S Lee;V Eapen
3 de junho de 2013
Tourette syndrome (TS) is a highly heritable neuropsychiatric disorder characterised by motor and vocal tics. Despite decades of research, the aetiology of TS has remained elusive. Recent successes in gene discovery backed by rapidly advancing genomic technologies have given us new insights into the...


Use of machine learning to shorten observation-based screening and diagnosis of autism
D P Wall; et al
3 de junho de 2013
The Autism Diagnostic Observation Schedule-Generic (ADOS) is one of the most widely used instruments for behavioral evaluation of autism spectrum disorders. It is composed of four modules, each tailored for a specific group of individuals based on their language and developmental level...


A novel blood-based biomarker for detection of autism spectrum disorders
N. Momeni; et al
3 de junho de 2013
Autism spectrum disorders (ASD) are classified as neurological developmental disorders. Several studies have been carried out to find a candidate biomarker linked to the development of these disorders, but up to date no reliable biomarker is available. Mass spectrometry techniques have been used...


Disorder-specific functional abnormalities during sustained attention in youth with Attention Deficit Hyperactivity Disorder (ADHD) and with Autism
A Christakou; et al
5 de maio de 2013
Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are often comorbid and share behavioural-cognitive abnormalities in sustained attention. A key question is whether this shared cognitive phenotype is based on common or different underlying...


Divalproex Sodium vs Placebo for the Treatment of Irritability in Children and Adolescents with Autism Spectrum Disorders
Eric Hollander; et al
1º de abril de 2013
Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by social and language deficits and by repetitive behaviors and interests. Irritability/aggression is a significant comorbid symptom in this population, which greatly impacts burden of care...


Differentiation between Autism and Multiple Complex Developmental Disorder in Response to Psychosocial Stress
Lucres MC Jansen; Christine C Gispen-de Wied; Rutger-Jan van der Gaag; Herman van Engeland
1º de abril de 2013
Multiple Complex Developmental Disorder (MCDD) represents a distinct group within the autistic spectrum based on symptomatology. Unlike autistic children, part of MCDD children develop schizophrenia in adult life. Despite the differences, patients of both disorders are mainly characterized by...


Revista Chilena de Psiquiatría y Neurología de la Infancia y Adolescencia - Abril/2011
Universidad de Chile Clínica Las Condes
12 de novembro de 2012
Revista Chilena de Psiquiatría y Neurología de la Infancia y Adolescencia - Abril/2011...


Translation and validation of Autism Diagnostic Interview-Revised (ADI-R) for autism diagnosis in Brazil
Michele M. Becker; et al
2 de julho de 2012
The landmark paper in autism came in 1942, when Kanner described a behavioral syndrome in eleven children...


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